This review covers history of therapeutic use, subjective and adverse medical effects, potential neurotoxicity and limitations in research into MDMA / ecstasy neurotoxicity, and was apparently written for a psychiatric or drug-abuse counselor audience. It is very well-written and nicely organized, but with uneven coverage of topics. Its strongest point are its mostly accurate recounting of the history of MDMA as a therapeutic and recreational drug, and a commentary on the difficulties of interpreting comparisons between ecstasy users and non-users as evidence of MDMA/ecstasy neurotoxicity. (Most of the discussion refers to assessment of 5HT function rather than cognitive function). However, this review contains the usual errors concerning the origins and appearance of MDMA/ecstasy use outside the therapeutic context, as well as probable errors concerning the percentage of the general population who have used ecstasy. As well, in the section discussing adverse events, the unlikely claim for MDMA fatalities reported in the 1970s is made. No mention is made of findings from clinical studies in describing the subjective effects of MDMA. The authors describe a number of common adverse effects, but they do not provide information on how to avoid or reduce risk of their occurring. Organization and accuracy are strong in some places and weak in others, making the review only moderately good in its entirety.