3,4-Methylenedioxymethamphetamine (MDMA)
A Review of the English-Language Scientific and Medical Literature



Reid Stuart, M.A.

July 13, 2001

MDMA Literature Review Update #1 (1/20/03)
MDMA Literature Review Update #2 (7/16/04)
MDMA Literature Review Update #3 (4/25/05)
MDMA Literature Review Update #4 (12/07) - New, with major revisions and reformatting
2008 Year-end Review of Literature (12/02/08)
2009 Year-end Review of Literature (3/28/2010)


View the PDF of the MDMA Literature Review (4.2 MB)


Part 1 - Table of Contents, Introduction and Chapter Summaries (303K)
Part 2 - Previous Human Experience: Controlled Clinical Trials and Pharmacology (865K)
Part 3 - Demographics and Self-Reported Effects of Illicit Ecstasy Use (471K)
Part 4 - MDMA Neurotoxicity: Studies in Nonhuman Animals (1M)
Part 5 - Neurotoxicity Research in Humans (376K)
Part 6 - Medical Emergencies and Adverse Events in Ecstasy Users (289K)
Part 7 - References (532K)
Part 8 - Appendices (973K)


  New - View the 2008 year-end literature review. The review provides information on studies appearing from December 2007 to late November 2008.

View the newest revision of the Investigators' Brochure, covering research published up through December 2007 and including pre-publications from 2008. This Investigator's Brochure is significantly streamlined and newly formatted.

View the PDF of the MDMA Literature Review Update #1: 1/20/03 (211K)

New MDMA Research at the Annual Meeting of CPDD, June 2003

View the PDF version of MDMA Literature Update #2 (January 2003-March 2004) 7/16/04.

View the HTML version of MDMA Literature Update #2 (January 2003-March 2004) 7/16/04. View the MDMA literature update #3, (March 2004-January 2005), in HTML or PDF format.

Updated Review of MDMA-Related Scientific Literature

Please note; Recent reviews and summaries of literature will no longer be stored in the Literature Updates section. They will now be found in the MAPS Bibliography. Reviews and sunmmaries can now be found as part of the information stored about new papers in the bibliography. Over the next few months, more reviews and summaries will appear. You can check out what's new by visiting the "What's New" section of the bibliography.