Antidepressant effects of ketamine in depressed patients

Investigators: Berman RM, Cappiello A, Anand A, Oren DA, Heninger GR, Charney DS, Krystal JH
Abraham Ribicoff Center Clinical Neuroscience Research Unit of theConnecticut Mental Health Center, New Haven 06519, USA
Seven subjects with major depression completed 2 test days that involved intravenous treatment with ketamine hydrochloride (.5 mg/kg) or saline solutions under randomized, double-blind conditions. RESULTS: Subjects with depression evidenced significant improvement indepressive symptoms within 72 hours after ketamine but not placebo infusion. CONCLUSIONS: These results suggest a potential role for NMDA receptor-modulating drugs in the treatment of depression.

  • Reference: Biol Psychiatry 2000 Feb 15;47(4):351-4.