On March 16, 2016, the Independent Review Board (IRB) approved the protocol for our upcoming study of MDMA-assisted psychotherapy for PTSD in couples. Taking place in Charleston, South Carolina, and led by Principal Investigator Michael Mithoefer, M.D., and Sub-Investigator Candice Monson, Ph.D., this will be a pilot Phase 1/Phase 2 open-label study exploring Cognitive-Behavioral Conjoint Therapy (CBCT) integrated with MDMA-assisted psychotherapy for the treatment of chronic posttraumatic stress disorder (PTSD). The study will enroll 10 participant pairs, each with one participant diagnosed with PTSD, and one concerned significant other without PTSD. MDMA will be administered to both participants to help facilitate communication and connection between participants and therapists. We anticipate starting the study in June 2016, once it has been approved by the Drug Enforcement Administration (DEA).