Sponsor: The Netherlands Organisation for Health Research and Development
Investigators: Glenn Dumont PhD, RJ Verkes PhD
Contact: Glenn Dumont (glenn.dumont@zuyd.nl)
Studies examined the physiological, subjective, acute cognitive and neuroendocrine effects of MDMA given alone and in combination with the THC (the active compound in cannabis) or ethanol in healthy volunteers reporting some experience with “ecstasy.” This project included the first report of elevated serum oxytocin after MDMA in a randomized, placebo controlled study.
- Dumont GJ, Wezenberg E, Valkenberg MM, de Jong CA, Buitelaar JK, van Gerven JM, Verkes RJ (2008) Acute neuropsychological effects of MDMA and ethanol (co-)administration in healthy volunteers. Psychopharmacology (Berl) 197:465-474.
- Dumont GJ, Kramers C, Sweep FC, Touw DJ, van Hasselt JG, de Kam M, van Gerven JM, Buitelaar JK, Verkes RJ (2009) Cannabis coadministration potentiates the effects of “ecstasy” on heart rate and temperature in humans. Clinical pharmacology and therapeutics 86:160-166.
- Dumont GJ, Sweep FC, van der Steen R, Hermsen R, Donders AR, Touw DJ, van Gerven JM, Buitelaar JK, Verkes RJ (2009) Increased oxytocin concentrations and prosocial feelings in humans after ecstasy (3,4-methylenedioxymethamphetamine) administration. Social neuroscience 4:359-366.
- Dumont GJ, Kramers C, Sweep FC, Willemsen JJ, Touw DJ, Schoemaker RC, van Gerven JM, Buitelaar JK, Verkes RJ (2010) Ethanol co-administration moderates 3,4-methylenedioxymethamphetamine effects on human physiology. J Psychopharmacol 24:165-174.
- Dumont GJ, Schoemaker RC, Touw DJ, Sweep FC, Buitelaar JK, van Gerven JM, Verkes RJ (2010) Acute psychomotor effects of MDMA and ethanol (co-) administration over time in healthy volunteers. J Psychopharmacol 24:155-164.
- Lansbergen MM, Dumont GJ, van Gerven JM, Buitelaar JK, Verkes RJ (2011) Acute effects of MDMA (3,4-methylenedioxymethamphetamine) on EEG oscillations: alone and in combination with ethanol or THC (delta-9-tetrahydrocannabinol). Psychopharmacology (Berl) 213(4):745-56.
