In Memoriam: Ann Shulgin, Forerunner of Today’s Psychedelic Re-Emergence, Dies at 91

Ann Shulgin, one of the foremost thinkers and authors to have guided the current resurgence of interest in psychedelics, died at home on July 9, 2022, in the company of people who loved her, at the age of 91.

Ann was the widow and co-conspirator of the legendary chemist Alexander “Sasha” Shulgin, Ph.D., and was the matriarch of a decades-old community of therapists, scientists, scholars, and explorers of the realms opened by psychedelic substances. It was Ann who best understood people and the complexities of the psyche, whereas Sasha was a genius in chemistry and psychopharmacology. When they met in 1978, Sasha had already created 2C-B, as well as many other psychedelic molecules. He had also rediscovered MDMA and had described its chemistry and psychoactive properties. He and Ann took note of the unique therapeutic potential of MDMA, thus beginning its launch into today’s prominence.

Ann pioneered the exploration of the therapeutic uses of MDMA and 2C-B, and of several related compounds, during a time when they were not illegal. As a lay therapist, she developed methods of working with these materials, incorporating concepts from Jungian psychoanalysis. She was skilled in doing shadow work with clients and was generous in mentoring other therapists in this process. Ann gave an influential presentation on shadow work at the 2019 Women’s Visionary Congress.

Together, Ann and Sasha conceived and authored two landmark books – PiHKAL: A Chemical Love Story (1991) and TiHKAL: The Continuation (1997) – telling stories of their relationship and their community, interwoven with recipes for Sasha’s molecular creations and descriptions of their properties contributed by collaborators. Established publishers considered PiHKAL too controversial to take on, so the Shulgins started their own imprint, Transform Press, to make the work public. It may be difficult to appreciate that, not long ago, psychedelics were not only demonized by governments and the media, but that enforcement of the prohibition of them was often truly draconian. PiHKAL raised their work to the attention of law enforcement. Sasha’s backyard laboratory was investigated, leading to a great deal of disruption and distress, ultimately to heavy fines, and thankfully nothing worse. Their second book, TiHKAL, opens with a recounting of this experience.

Ann was born Laura Ann Gotlieb in New Zealand on March 22, 1931. Her mother was a New Zealander and her father a U.S. Consul. As a result of her father’s profession, Ann had an international upbringing. She settled in San Francisco in her twenties, where she studied art, married an art student, and had a son, Christopher McRee. In 1960, Ann married Jungian psychoanalyst John Weir Perry, with whom she had three children: Alice Garofalo, Wendy Tucker, and Brian Perry. Ann and John separated in 1969.

Ann is survived by her children, eight grandchildren, five great-grandchildren, and by the countless community members for whom she has been a maternal figure, master teacher, and an ethical compass. 

Ann married Sasha in the garden of the Shulgin Farm in Lafayette, California, on July 4, 1981, and their wedding anniversary became, along with Easter Sunday, an occasion for yearly gatherings of the community of scientists, scholars, and practitioners working with psychedelics, against cultural currents, to meet and to talk. Wednesday Night Dinners (later changed to Friday Night Dinners) began as periodic gatherings for family and extended family, expanding over the years to potluck gatherings for the larger community. The Shulgins served as upstanding parental figures, especially for people whose own families did not understand or support their interest in psychedelics. Ann and Sasha were remarkably inclined to maintain open and friendly relations with a diverse collection of community groups, even when there was competition or factionalization among them. Only in the case of one deeply reprehensible behavior, that of spying and reporting on someone for the government, did Ann close the door on the famed Shulgin hospitality. 

Ann modeled how to live as a good citizen in the psychedelic community. Kind, generous, present in connection, an exemplary therapist, and a wise mentor, her big heart shown through in the sparkle in her eyes. She loved her family above all, her husband, her children, and her grandchildren. And she loved those around her. In return, she was surrounded by a circle of love and care to the hours of her last breath and beyond.

The Shulgin family suggests that anyone wishing to honor Ann’s life and contributions do so with a gift to the Women’s Visionary Council (WVC). Since 2008, with Ann’s support, the WVC has successfully highlighted the vital roles of women in psychedelics, has honored the field’s women pioneers, and has encouraged more women to enter the field.


David Presti teaches biology, psychology, and cognitive science at the University of California, Berkeley, where he has been on the faculty in molecular and cell biology for more than 30 years. For more than a decade, he worked in the clinical treatment of addiction and of posttraumatic stress disorder at the Department of Veterans Affairs Medical Center in San Francisco. And since 2003, Presti has been teaching neuroscience and conversing about science with Tibetan Buddhist monastics in India, Bhutan, and Nepal. Presti has a doctorate in molecular biology and biophysics from Caltech, and another in clinical psychology from the University of Oregon. Presti’s areas of expertise include human neurobiology and neurochemistry, the effects of drugs on the brain and the mind, the clinical treatment of addiction, and the scientific study of mind and consciousness.

Mariavittoria Mangini, Ph.D., F.N.P., has written extensively on the impact of psychedelic experiences in shaping the lives of her contemporaries, and has worked closely with many of the most distinguished investigators in this field. She is a founder of the Women’s Visionary Council, a nonprofit organization that supports investigations into non-ordinary forms of consciousness and organizes gatherings of researchers, healers, artists, and activists whose work explores these states. Her long history with the Haight Ashbury Free Clinic includes having been a barefoot patient, a lead clinician in the medical section, and the chair of the Board of Directors – all in the same lifetime. She has been a Family Nurse Midwife for 35 years, and was in primary care practice with Frank Lucido MD, one of the pioneers of the medical cannabis movement, for 25 years. Their practice was one of the first to implement the California Compassionate Use Act of 1996, the first state medical cannabis initiative. She is Professor Emerita of Nursing at Holy Names University in Oakland. Her current project is the development of a Thanatology program for the study of death and dying.

Bob Jesse has long been a quiet, guiding force behind the contemporary psychedelic renaissance. He was instrumental in forming the psilocybin research team at Johns Hopkins, helped to set its course, co-authored its influential 2006 paper among others, and continues as part of that team. He has led the drafting of foundational documents: a Code of Ethics for Spiritual Guides (1995), an amicus brief (2005) for the U.S. Supreme Court in a successful religious liberty case, and a statement on Open Science (2017) now signed by numerous leaders in the field. He has served on boards and advises various individuals and groups in the space, including the new Berkeley Center for the Science of Psychedelics. Earlier in life, Bob trained at Hopkins in electrical engineering and computer science, consulted for AT&T Bell Labs, and worked at Oracle as a VP of business development.